Decoding antibody signatures

Antibodies are biomarkers that can be used to detect disease earlier and guide treatment decisions

HUMORAL IMMUNITY

 

The humoral immune system monitors and regulates human health via antibodies.

The vast repertoire of antibodies represents the immune response to antigens including viruses, bacteria and allergens, as well as diseases including cancers, neurological, autoimmune, infectious and inflammatory diseases.

IPDx proprietary technology translates the intricate collection of antibodies into actionable data to develop diagnostics that help detect disease earlier and guide treatment decisions.

TECHNOLOGY

 

Our core technology Mimotope Variation analysis (MVA) combines random peptide phage display library screening, next-generation sequencing, and big data analytics to decode antibody signatures.

Antibody screening. Biological samples (blood, urine, saliva etc.) containing antibodies are screened against peptide phage display library containing 1010 peptides, mimicking the billions of naturally occurring antigens. Phage DNA encoding the displayed peptide sequence is isolated from antibody bound phages and sequenced to identify the antibody bound epitope peptides.

Data analysis. Epitope peptide sequences are analyzed using advanced computational methods to identify disease-specific epitope/mimotope sequences and sequence motifs. The disease-specific epitope peptides and motifs may represent both antigens of functional antibodies involved in disease-causing pathways and antibodies that reflect downstream pathway changes related to the disease.

Our understanding of the antibody repertoire is ever growing with each MVA analysis. Every consecutive analysis is added to our database enhancing the computational power of MVA and delivering further insight into disease mechanisms.

Diagnostics. Leveraging the disease-specific peptides we can develop diagnostics to reveal antibody signatures that represent a variety of diseases including cancers, autoimmune, neurological, infectious and inflammatory diseases.

PARTNERING

IPDx collaborates with partners interested in:

  • Basic immune-research
  • Vaccine development including antigen discovery and safety and efficacy studies
  • Biomarker discovery
  • Multiplex diagnostic panels

Collaborators include academia, biopharma, and healthcare companies.

Contact us to hear more
christof.neuman@ipdx.eu

 

IPDx, in 2016, was awarded a grant from Sächsische Aufbaubank to develop multi-biomarker point of care tests targeting different types of cancer.